課程名稱 |
神經電氣生理學 Neuroeletrophysiology |
開課學期 |
100-1 |
授課對象 |
生物資源暨農學院 獸醫學研究所 |
授課教師 |
張芳嘉 |
課號 |
VM5062 |
課程識別碼 |
629 U2040 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
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上課地點 |
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備註 |
上課時間地點另訂。 總人數上限:20人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1001electrophysiol |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course will discuss the fundamental concept of electrophysiology, including basic electricity, neuronal properties and morphology, membrane potential, the passive properties of neuronal membrane, the generation of action potential, the microelectrode recording techniques (current clamp, voltage clamp and patch clamp recordings), ion channels and their kinetic properties (sodium channel, potassium channel and calcium channel), synaptic transmission, quantal properties of transmitter release, synaptic plasticity (long-term potentiation and long-term depression), and electroencephalogram (EEG) and electromyogram (EMG): the theory and their clinical applications. |
課程目標 |
1 Membrane Property
2 Membrane Potentials
3 Ion Channels: Passive membrane property
4 Ion Channels: Voltage-gate ion channels
5 Mechanisms of Transmitter Release
6 Synaptic Vehicle
7 Synaptic Transmission
8 Synaptic Interaction and Synaptic Plasticity
9 Long-term potentiation & long-term depression
10 Techniques of Electrophysiology
11 Macroelectrophysiological technique: EEG & EMG
12 EEG & EMG application in seizure and sleep
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課程要求 |
Prerequisite: Physiology |
預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Principle of Neural Science: by Eric Kandel, James H. Schwartz and Thomas M Jessel, Fourth Edition, McGraw-Hill Co., (2000)
2. The Physiology of Excitable cells: by David J. Aidley, Third Edition, Cambridge University Press, (1991)
3. From Neuron to Brain: by John G. Nicholls, A. Robert Martin and Bruce G. Wallace, Third Edition, Sinauer Associates, Inc., (1992).
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評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Participation |
20% |
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2. |
Class discussion |
20% |
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3. |
Debate/presentation |
30% |
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4. |
Term paper |
30% |
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週次 |
日期 |
單元主題 |
第1週 |
9/15 |
Introduction/concentration cells |
第2週 |
9/22 |
Neuron features/general properties of ion channels |
第3週 |
9/29 |
Membrane potential/passive electric properties |
第4週 |
10/6 |
Generation of action potential |
第5週 |
10/13 |
Recording techniques |
第6週 |
10/20 |
Ionic channels: Sodium channel |
第7週 |
10/27 |
Ionic channels: potassium channel & calcium channel |
第8週 |
11/3 |
Neurotransmitters |
第9週 |
11/10 |
Mid-term examination (no class) |
第10週 |
11/17 |
Synaptic transmission |
第11週 |
11/24 |
Synaptic plasticity |
第12週 |
12/1 |
Macroelectrophysiology: EEG & EMG |
第13週 |
12/8 |
Presentation I: Channelopathy - Dravet syndrome:
Classification, sign & symptoms, causes &
pathophysiology, treatment |
第14週 |
12/15 |
Presentation II: Multiple sclerosis:
Classification, sign & symptoms, causes &
pathophysiology, treatment |
第15週 |
12/22 |
Presentation III: Synaptic plasticity & sleep |
第16週 |
12/29 |
Class will be re-scheduled |
第17週 |
1/5 |
Presentation IV: Sleep enhances memory consolidation |
第18週 |
1/12 |
Final examination (no class) |
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